The Chemical Biology of DNA Damage


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DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology. - PubMed - NCBI

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Review ARTICLE

Engen, and Penny J. The research in the Beuning laboratory encompasses the following areas: We aim to determine how cells respond to DNA damage and maintain the accuracy of genetic information, by studying the specificity of DNA-damage bypass Y-family DNA polymerases for different types of damage, by probing interactions between DNA replication and DNA damage tolerance, and by determining the genes responsible for tolerance to specific DNA damaging agents.

Penny Beuning in the news Penny Beuning and Mary Jo Ondrechen, Northeastern professors of chemistry and chemical biology, are developing new ways to predict the function of an enzyme by looking at the roles of the individual amino acids that make up its structure.

Scientist explores DNA damage and repair

Biochemistry , Biotechnology , Chemistry and Chemical Biology They Want to Reveal the Chemistry of Every Enzyme Ever Professor of chemistry and chemical biology at Northeastern are using a combination of computational predictions and experimental testing to explore the connection between the chemical make-up of an enzyme and its function. Photo courtesy of Kathleen Kenney. Penny Beuning, associate professor of Chemistry and Chemical Biology. Current Opinion in Chemical Biology [15 Jun , 11 3 ].

Abstract Diverse small molecules alkylate DNA and form covalently linked adducts that can influence crucial biological processes, contributing to toxicity and mutation. Understanding the chemical reactivity dictating DNA alkylation and interactions of adducts with biological pathways can impact disease prevention and treatment. The ambident reactivity of DNA-alkylating small molecules, and of DNA itself, often results in formation of multiple adducts.

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Determining which structures impart biological responses is important for understanding the underlying relationships between small-molecule structure and biology. With application of sensitive and structure-specific experimental and analytical methodology, such as heteronuclear NMR spectroscopy and mass spectrometry, there are increasing numbers of studies that evaluate DNA alkylation from the perspective of resulting adduct profiles.

DNA adduct profiles have been examined for both exogenous and endogenous reactive small molecules. Examples of recent findings are in the areas of tobacco-specific carcinogens, lipid peroxidation products, environmental and dietary chlorophenols, and natural-product-derived antitumor therapies. CA

The Chemical Biology of DNA Damage The Chemical Biology of DNA Damage
The Chemical Biology of DNA Damage The Chemical Biology of DNA Damage
The Chemical Biology of DNA Damage The Chemical Biology of DNA Damage
The Chemical Biology of DNA Damage The Chemical Biology of DNA Damage
The Chemical Biology of DNA Damage The Chemical Biology of DNA Damage
The Chemical Biology of DNA Damage The Chemical Biology of DNA Damage

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